Cryptococcosis

Cryptococcosis









Prer ard by: Tarig Mohamed Ageeb

Cryptococcosis



Cryptococcusneoformans:
A Capsulated barm A align yeast..
A sporadic disease in the past.
Most habitual infection in AIDS patients.





Morphology
A true yeast
Round 4 10 microns
Surrounded by Mucopolysaccharide capsule.
cryptical in vivo
Negative staining with India Ink and Nigrosin
60% of the infect prove positive by India Ink preparation on examination of CSF
KoH preparations in Sputum and other tissues,
PAS and Mucicaramine staining helps confirmation.


Cryptococcus neoformans
Distribution
origination wide distribution.

IN SUDAN:
In 1971 two cases of cryptococcal pneumonia in horses are described. Histoplasma farciminosum was isolated from both cases.
The diagnosis was based on histopathological changes in the lungs and culture of the fungus.

Cryptococcus neoformans
Serotypes
A true yeast
4 serotypes - A,B,C,D
A and D - C.neofromans volt-ampere neoformans
B and C - C.neoformans var gatti.
many another(prenominal) infections are caused by
C.neofromans var neoformans.




Found in uncivilized/Domesticated birds.
Pigeons carry C.neofromans,
Birds do not occupy infected.
Commercialy functional AB tests

Serotype
A 80% clinical cases
B tropical, semitropical S. California, Hawaii, Brazil, Australia, SE Asia
C rare
D Europe Denmark, Germany, Italy, France, Switzerland

Ecology:
C.neoformans var neoformans: pigeons- parrots- canaries.
C.neoformans var gatii:oaks-eukalyptus- maples-firs.




Transmission
Inhalation Intensive bird exposure realm
Needlestick injury
Organ transplant


Pathogenesis
Enters through lungs - inhalation of Basidiospores of C neoformans.
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