How Can Disruption of Transcription Factor Function Lead to Development of Leukemia?

Introduction

Hematopoiesis is the process of continuous production of blood cells during the wide life span of an individual; it depends on a image of r ar pluripotential cell, hematopoietic stem cell (HSC), whose abundance is tightly regulated by several processes, including self-renewal, proliferation, lineage specification, differentiation, maturation and apoptosis.

haematological malignancy arises when the normal regulatory processes of hematopoiesis lose its control, accumulating deviant blood cells in bone marrow and circulation (Downing and Shannon, 2002). Leukemias are a type of hematological disease characterized by clonal magnification of white cells which undergone genetic alterations. The detailed mechanism of leukemogenesis remains more often than not unknown; however it is believed that the malignancy development depends on the conspiracy of genetic background and environmental factors. Leukemia can be sort out into four types, acute and chronic leukemias, which are further subdivided into lymphoid or myeloid lineages.

Genetic Mutations in Leukemia Chromosomal Abnormalities, make-up of Oncogene and Dysregulation of Tumor Suppressor Gene

As mentioned, malignant faulting occurs as a result of the accumulation of genetic mutations in cellular genes.



These genetic mutations include chromosomal translocation, inversion, deletion, gene enlargement and point mutations. The genes that are involved in the development of crab louse can be divided broadly into two groups, oncogene and tumor-suppressor gene. During normal hematopoiesis, proliferation of blood cells depends on a equilibrise amid the action of proto-oncogenes and tumor suppressor genes. In malignant cell, this balance is disturbed leading to uncontrolled cell division.

Oncogene is derived from proto-oncogene which undergone gain-of-function mutation. Proto-oncogenes are involved in a variety of important cellular processes, often in the signal transduction pathway for gene activation....If you motive to get a full essay, order it on our website: Orderessay



If you want to get a full essay, wisit our page: write my essay .